Identification of pro-inflammatory CD205⁺ macrophages in livers of hepatitis B virus transgenic mice and patients with chronic hepatitis B.

ABSTRACT: Hepatic macrophages play a central role in disease pathogenesis during hepatitis B virus (HBV) infection. Our previous study found that CD205⁺ macrophages in the liver of hepatitis B surface antigen transgenic (HBs-Tg) mice increased significantly compared with those in wild-type mice, and these increased CD205⁺ macrophages were involved in CpG-oligodeoxynucleotide-induced liver injury in HBs-Tg mice. Here, we analysed the phenotype and function of CD205⁺ macrophages derived from the liver of HBs-Tg mice and patients with chronic hepatitis B (CHB). We found that HBs-Tg mice-derived hepatic macrophages produced larger amounts of pro-inflammatory cytokines, including IL-6, IL-12, TNF-α, and of the anti-inflammatory cytokine IL-10 after stimulation with CpG-ol

SUBMITTER: Yong L 

PROVIDER: S-EPMC5402278 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature