Recovery sleep after extended wakefulness restores elevated A₁ adenosine receptor availability in the human brain.

ABSTRACT: Adenosine and functional A₁ adenosine receptor (A₁AR) availability are supposed to mediate sleep-wake regulation and cognitive performance. We hypothesized that cerebral A₁AR availability after an extended wake period decreases to a well-rested state after recovery sleep. [¹⁸F]CPFPX positron emission tomography was used to quantify A₁AR availability in 15 healthy male adults after 52 h of sleep deprivation and following 14 h of recovery sleep. Data were additionally compared with A₁AR values after 8 h of baseline sleep from an earlier dataset. Polysomnography, cognitive performance, and sleepiness were monitored. Recovery from sleep deprivation was associated with a decrease in A₁AR availability in several brain r

SUBMITTER: Elmenhorst D 

PROVIDER: S-EPMC5402442 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature