Delivering strong ¹H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange.

ABSTRACT: Hyperpolarization turns typically weak NMR and MRI responses into strong signals so that ordinarily impractical measurements become possible. The potential to revolutionize analytical NMR and clinical diagnosis through this approach reflect this area's most compelling outcomes. Methods to optimize the low-cost parahydrogen-based approach signal amplification by reversible exchange with studies on a series of biologically relevant nicotinamides and methyl nicotinates are detailed. These procedures involve specific ²H labeling in both the agent and catalyst and achieve polarization lifetimes of ca 2 min with 50% polarization in the case of methyl-4,6-d₂ -nicotinate. Because a 1.5-T hospital scanner has an effective ¹H polarization level o

SUBMITTER: Rayner PJ 

PROVIDER: S-EPMC5402466 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature