Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes.

ABSTRACT: Peritonitis remains the major obstacle for the maintenance of long-term peritoneal dialysis and dysregulated host peritoneal immune responses may compromise local anti-infectious defense, leading to treatment failure. Whilst, tissue mononuclear phagocytes, comprising macrophages and dendritic cells, are central to a host response to pathogens and the development of adaptive immune responses, they are poorly characterized in the human peritoneum. Combining flow cytometry with global transcriptome analysis, the phenotypic features and lineage identity of the major CD14⁺ macrophage and CD1c⁺ dendritic cell subsets in dialysis effluent were defined. Their functional specialization was reflected in cytokine generation, phagocytosis, and antigen processing/presentation. By

SUBMITTER: Liao CT 

PROVIDER: S-EPMC5402633 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature