Chlamydia spp. development is differentially altered by treatment with the LpxC inhibitor LPC-011.

ABSTRACT:

Background

Chlamydia species are obligate intracellular bacteria that infect a broad range of mammalian hosts. Members of related genera are pathogens of a variety of vertebrate and invertebrate species. Despite the diversity of Chlamydia, all species contain an outer membrane lipooligosaccharide (LOS) that is comprised of a genus-conserved, and genus-defining, trisaccharide 3-deoxy-D-manno-oct-2-ulosonic acid Kdo region. Recent studies with lipopolysaccharide inhibitors demonstrate that LOS is important for the C. trachomatis developmental cycle during RB- > EB differentiation. Here, we explore the effects of one of these inhibitors, LPC-011, on the developmental cycle of five chlamydial species.

Results

Sensitivity to the drug varied in some of the species and was conserve

SUBMITTER: Cram ED 

PROVIDER: S-EPMC5402638 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature