N of 1 trials and the optimal individualisation of drug treatments: a systematic review protocol.

ABSTRACT:

Background

Guidelines and evidence-based drug treatment recommendations are usually based on the results of clinical trials, which have limited generalisability in routine clinical settings due to their restrictive eligibility criteria. These trials are also conducted in ideal and rigorously controlled settings. N of 1 trials, which are single patient multiple crossover studies, offer a means of increasing the evidence base and individualising care for individuals in clinical practice. This systematic review of the N of 1 drug treatment trial aims to investigate its usefulness for achieving optimal individualised patient care.

Methods

The following databases will be searched for relevant articles: MEDLINE, EMBASE, PsycINFO (all via Ovid), AMED, CINAHAL (via EBSCO), The Cochr

SUBMITTER: Demeyin WA 

PROVIDER: S-EPMC5402671 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature