Caspofungin-Non-Susceptible Candida orthopsilosis Isolated from Onychomycosis in Iran.

ABSTRACT:

Background

Although Candida albicans remains the most common fungal isolate from clinical specimens, many studies have detected a shift towards non-albicans Candida species. Despite worrying clinical pictures associated with latter species, there is little information regarding its susceptibility patterns against currently available antifungal agents, with only a small number of strains having been studied.

Methods

We evaluated the in vitro antifungal susceptibilities of clinical isolates of C. orthopsilosis already identified by two-steps PCR-RFLP and reconfirmed by sequence analysis of entire ITS rDNA region, to six antifungal drugs.

Results

The resulting MIC₅₀ and MIC₉₀ for all strains (n=18) were in increasing orde

SUBMITTER: Mohammadi R 

PROVIDER: S-EPMC5402783 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature