Relationship between early onset severe intrahepatic cholestasis of pregnancy and higher risk of meconium-stained fluid.

ABSTRACT:

Background

Intrahepatic cholestasis of pregnancy (ICP) is the commonest gestational liver disease. The risk of adverse fetal outcome has been associated with the severity of maternal hypercholanemia after diagnosis.

Objective

To investigate whether there is a relationship between the severity and timing of onset of hypercholanemia and the risk of meconium-stained amniotic fluid (MSAF) and adverse neonatal events.

Study design

The study included 382 pregnancies complicated by ICP managed at a referral hospital in Buenos Aires (Argentina) between June 2009 and December 2013. The patients were classified into three groups according to the severity of hypercholanemia at diagnosis; mild (10-19.9 μmol/L), moderate (20-39.9 μmol/L) and severe (≥40 μmol/L). Their clinical cha

SUBMITTER: Estiu MC 

PROVIDER: S-EPMC5402936 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature