Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium.

ABSTRACT: Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failure. Combined macrolide/fluoroquinolone-resistance mutations were in 8.6% of specimens, for which recommended therapies would be ineffective.

SUBMITTER: Murray GL 

PROVIDER: S-EPMC5403035 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature