Cerebral Cortex Regions Selectively Vulnerable to Radiation Dose-Dependent Atrophy.

ABSTRACT:

Purpose and objectives

Neurologic deficits after brain radiation therapy (RT) typically involve decline in higher-order cognitive functions such as attention and memory rather than sensory defects or paralysis. We sought to determine whether areas of the cortex critical to cognition are selectively vulnerable to radiation dose-dependent atrophy.

Methods and materials

We measured change in cortical thickness in 54 primary brain tumor patients who underwent fractionated, partial brain RT. The study patients underwent high-resolution, volumetric magnetic resonance imaging (T1-weighted; T2 fluid-attenuated inversion recovery, FLAIR) before RT and 1 year afterward. Semiautomated software was used to segment anatomic regions of the cerebral cortex for each patient. Cortical thickn

SUBMITTER: Seibert TM 

PROVIDER: S-EPMC5403140 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature