Influence of Oral Progesterone Administration on Drug-Induced QT Interval Lengthening: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.

ABSTRACT:

Objectives

We tested the hypothesis that oral progesterone administration attenuates drug-induced QT interval lengthening.

Background

Evidence from preclinical and human investigations suggests that higher serum progesterone concentrations may be protective against drug-induced QT interval lengthening.

Methods

In this prospective, double-blind, crossover study, 19 healthy female volunteers (21-40 years) were randomized to receive progesterone 400 mg or matching placebo orally once daily for 7 days timed to the menses phase of the menstrual cycle (between-phase washout period = 49 days). On day 7, ibutilide 0.003 mg/kg was infused over 10 minutes, after which QT intervals were recorded and blood samples collected for 12 hours. Prior to the treatment phases, subjects un

SUBMITTER: Tisdale JE 

PROVIDER: S-EPMC5403156 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature