Chronotropic Incompetence and Risk of Atrial Fibrillation: The Henry Ford ExercIse Testing (FIT) Project.

ABSTRACT:

Objectives

To examine the association between chronotropic incompetence and incident atrial fibrillation (AF).

Background

Patients with inadequate heart rate response during exercise may have abnormalities in sinus node function or autonomic tone that predispose to the development of AF.

Methods

We examined the association between heart rate response and incident AF in 57,402 (mean age=54±13 years, 47% female, 64% white) patients free of baseline AF who underwent exercise-treadmill stress testing from the Henry Ford ExercIse Testing (FIT) Project. Age-predicted maximum heart rate (pMHR) values <85% and chronotropic index values <80% were used to define chronotropic incompetence. Cox regression, adjusting for demographics, cardiovascular risk factors, medications, coro

SUBMITTER: O'Neal WT 

PROVIDER: S-EPMC5403158 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature