High-glucose levels and elastin degradation products accelerate osteogenesis in vascular smooth muscle cells.

ABSTRACT: Diabetes mellitus (DM) is a chronic disease in which the body either does not use or produce the glucose metabolising hormone insulin efficiently. Calcification of elastin in the arteries of diabetics is a major predictor of cardiovascular diseases. It has been previously shown that elastin degradation products work synergistically with transforming growth factor-beta 1 (TGF-β1) to induce osteogenesis in vascular smooth muscle cells. In this study, we tested the hypothesis that high concentration of glucose coupled with elastin degradation products and TGF-β1 (a cytokine commonly associated with diabetes) will cause a greater degree of osteogenesis compared to normal vascular cells. Thus, the goal of this study was to analyse the effects of high concentration of glucose, elastin peptides a

SUBMITTER: Sinha A 

PROVIDER: S-EPMC5403374 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature