Antiarrhythmic effects of interleukin 1 inhibition after myocardial infarction.

ABSTRACT:

Background

Interleukin 1β (IL-1β) is a key regulator of the inflammatory response after myocardial infarction (MI) by modulating immune cell recruitment, cytokine production, and extracellular matrix turnover. Elevated levels of IL-1β are associated with adverse remodeling, and inhibition of IL-1 signaling after MI results in improved contractile function.

Objective

The goal of this study was to determine whether IL-1 signaling also contributes to post-MI arrhythmogenesis.

Methods

MI was created in 2 murine models of elevated inflammation: atherosclerotic on the Western diet or wild-type with a subseptic dose of lipopolysaccharide. The role of IL-1β was assessed with the IL-1 receptor antagonist anakinra (10 mg/(kg·d), starting 24 hours post-MI).

Results

In viv

SUBMITTER: De Jesus NM 

PROVIDER: S-EPMC5403568 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature