Dense calcium and lesion-specific ischemia: A comparison of CCTA with fractional flow reserve.

ABSTRACT:

Background and aims

Studies evaluating the relationship between dense coronary calcium (DC) and myocardial ischemia have had incongruent results. We sought to clarify whether DC, as detected by computed coronary tomographic angiography (CCTA), is an independent predictor of ischemia as measured by invasive fractional flow reserve (FFR).

Methods

In total, 249 (399 lesions) stable patients undergoing CCTA and invasive FFR were enrolled for this post-hoc analysis. DC was defined as plaque with ≥350 HU using quantification software, and ischemia was defined as FFR ≤0.80. We evaluated the relationship of dense calcium volume (DCV), lesion plaque volume (LPV), non-calcified plaque volume (NCV), and area stenosis (AS) with ischemia using logistic regression reporting odds ratios (O

SUBMITTER: Baskaran L 

PROVIDER: S-EPMC5403580 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature