Radiomic features from the peritumoral brain parenchyma on treatment-naive multi-parametric MR imaging predict long versus short-term survival in glioblastoma multiforme: Preliminary findings.

ABSTRACT:

Objective

Despite 90 % of glioblastoma (GBM) recurrences occurring in the peritumoral brain zone (PBZ), its contribution in patient survival is poorly understood. The current study leverages computerized texture (i.e. radiomic) analysis to evaluate the efficacy of PBZ features from pre-operative MRI in predicting long- (>18 months) versus short-term (<7 months) survival in GBM.

Methods

Sixty-five patient examinations (29 short-term, 36 long-term) with gadolinium-contrast T_1w, FLAIR and T_2w sequences from the Cancer Imaging Archive were employed. An expert manually segmented each study as: enhancing lesion, PBZ and tumour necrosis. 402 radiomic features (capturing co-occurrence, grey-level dependence and directional gradients) were obtained for each regi

SUBMITTER: Prasanna P 

PROVIDER: S-EPMC5403632 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature