Maternal pre-pregnancy body mass index and circulating microRNAs in pregnancy.

ABSTRACT:

Background

Maternal pre-pregnancy overweight and obese status has been associated with a number of pregnancy complications and adverse offspring outcomes. Mechanisms for observed associations, however, are largely unknown. We investigated associations of pre-pregnancy body mass index with early-mid pregnancy epigenetic biomarkers, circulating microRNAs.

Methods

Peripheral blood was collected from participants (16-27 weeks gestation) of two multi-racial pregnancy cohorts, the Omega Study and the Pregnancy Outcomes and Community Health Study. Plasma miRNA expression was characterised using epigenome-wide (319 miRNAs) profiling among 20 pregnant women in each cohort. Cohort-specific linear regression models that included the predictor (pre-pregnancy body mass index), the outcom

SUBMITTER: Enquobahrie DA 

PROVIDER: S-EPMC5403633 | biostudies-literature | 2017 Jul - Aug

REPOSITORIES: biostudies-literature