Dipeptidyl peptidase-4 inhibitors and the risk of heart failure: a systematic review and meta-analysis.

ABSTRACT:

Background

Given recent discrepant results from randomized controlled trials (RCTs), we examined the totality of RCT evidence assessing the association between dipeptidyl peptidase-4 (DPP-4) inhibitors and heart failure.

Methods

MEDLINE, Embase and ClinicalTrials.gov were searched without language restrictions to August 2016 for RCTs comparing DPP-4 inhibitors to placebo or no therapy for a period of 24 weeks or more. We included all heart failure outcomes when listed either as a serious adverse event or adverse event. Pooled analyses used random-effects.

Results

We identified 100 RCTs (n = 79 867) - 3 large cardiovascular-safety RCTs (SAVOR-TIMI 53[saxagliptin]/n = 16 492, EXAMINE[alogliptin]/n = 5380, and TECOS[sitagliptin]/n = 14 735), a

SUBMITTER: Verma S 

PROVIDER: S-EPMC5403656 | biostudies-literature | 2017 Jan-Mar

REPOSITORIES: biostudies-literature