A gene-environment interaction analysis of plasma selenium with prevalent and incident diabetes: The Hortega study.

ABSTRACT:

Background

Selenium and single-nucleotide-polymorphisms in selenoprotein genes have been associated to diabetes. However, the interaction of selenium with genetic variation in diabetes and oxidative stress-related genes has not been evaluated as a potential determinant of diabetes risk.

Methods

We evaluated the cross-sectional and prospective associations of plasma selenium concentrations with type 2 diabetes, and the interaction of selenium concentrations with genetic variation in candidate polymorphisms, in a representative sample of 1452 men and women aged 18-85 years from Spain.

Results

The geometric mean of plasma selenium levels in the study sample was 84.2µg/L. 120 participants had diabetes at baseline. Among diabetes-free participants who were not lost during

SUBMITTER: Galan-Chilet I 

PROVIDER: S-EPMC5403796 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature