Identification of brain regions predicting epileptogenesis by serial [¹⁸F]GE-180 positron emission tomography imaging of neuroinflammation in a rat model of temporal lobe epilepsy.

ABSTRACT: Excessive activation of inflammatory signaling pathways seems to be a hallmark of epileptogenesis. Positron emission tomography (PET) allows in vivo detection of brain inflammation with spatial information and opportunities for longitudinal follow-up scanning protocols. Here, we assessed whether molecular imaging of the 18 kDa translocator protein (TSPO) can serve as a biomarker for the development of epilepsy. Therefore, brain uptake of [¹⁸F]GE-180, a highly selective radioligand of TSPO, was investigated in a longitudinal PET study in a chronic rat model of temporal lobe epilepsy. Analyses revealed that the influence of the epileptogenic insult on [¹⁸F]GE-180 brain uptake was most pronounced in the earlier phase of epileptogenesis. Differences were evident in variou

SUBMITTER: Russmann V 

PROVIDER: S-EPMC5403805 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature