Multirate method for co-simulation of electrical-chemical systems in multiscale modeling.

ABSTRACT: Multiscale modeling by means of co-simulation is a powerful tool to address many vital questions in neuroscience. It can for example be applied in the study of the process of learning and memory formation in the brain. At the same time the co-simulation technique makes it possible to take advantage of interoperability between existing tools and multi-physics models as well as distributed computing. However, the theoretical basis for multiscale modeling is not sufficiently understood. There is, for example, a need of efficient and accurate numerical methods for time integration. When time constants of model components are different by several orders of magnitude, individual dynamics and mathematical definitions of each component all together impose stability, accuracy and efficiency challen

SUBMITTER: Brocke E 

PROVIDER: S-EPMC5403853 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature