Cellular Antiviral Factors that Target Particle Infectivity of HIV-1.

ABSTRACT:

Background

In the past decade, the identification and characterization of antiviral genes with the ability to interfere with virus replication has established cell-intrinsic innate immunity as a third line of antiviral defense in addition to adaptive and classical innate immunity. Understanding how cellular factors have evolved to inhibit HIV-1 reveals particularly vulnerable points of the viral replication cycle. Many, but not all, antiviral proteins share type I interferon-upregulated expression and sensitivity to viral counteraction or evasion measures. Whereas well-established restriction factors interfere with early post-entry steps and release of HIV-1, recent research has revealed a diverse set of proteins that reduce the infectious quality of released particles using indivi

SUBMITTER: Goffinet C 

PROVIDER: S-EPMC5403965 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature