Ontology highlight
ABSTRACT:
SUBMITTER: Kasper DM
PROVIDER: S-EPMC5404386 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Developmental cell 20170301 6
Proper functioning of an organism requires cells and tissues to behave in uniform, well-organized ways. How this optimum of phenotypes is achieved during the development of vertebrates is unclear. Here, we carried out a multi-faceted and single-cell resolution screen of zebrafish embryonic blood vessels upon mutagenesis of single and multi-gene microRNA (miRNA) families. We found that embryos lacking particular miRNA-dependent signaling pathways develop a vascular trait similar to wild-type, but ...[more]