Characterization of the pJB12 Plasmid from Pseudomonas aeruginosa Reveals Tn6352, a Novel Putative Transposon Associated with Mobilization of the bla_VIM-2-Harboring In58 Integron.

ABSTRACT: The bla_VIM-2-carrying In58 integron has been linked to a chromosomal location in different bacterial species, including Pseudomonas aeruginosa This work reports the first fully sequenced In58-harboring plasmid, which is significantly different from the two previously identified bla_VIM-2-carrying plasmids in P. aeruginosabla_VIM-2 might have been acquired by transposition of Tn6352, a novel transposon composed of the In58 and ISPa17 elements. The recognition of similar inverted repeat (IR) sites by ISPa17 reveals a common mobilization process associated with acquisition of the bla_VIM-2 and bla_VIM-1 genes.

SUBMITTER: Botelho J 

PROVIDER: S-EPMC5404595 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature