Dataset Information
First Report of the Carbapenemase Gene blaOXA-499 in Acinetobacter pittii.
Ontology highlight
ABSTRACT:
SUBMITTER: D'Souza R
PROVIDER: S-EPMC5404604 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
First Report of the Carbapenemase Gene <i>bla</i><sub>OXA-499</sub> in Acinetobacter pittii.
Antimicrobial agents and chemotherapy 20170424 5
We identified the carbapenemase gene <i>bla</i><sub>OXA-499</sub>, a variant of <i>bla</i><sub>OXA-143</sub>, from a clinical isolate of <i>Acinetobacter pittii</i> for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible <i>Acinetobacter</i> spp., we were able to show that OXA-499 confers resistance to carbapenems. ...[more]