Cancer Risk After Pediatric Solid Organ Transplantation.

ABSTRACT:

Background

The effects of pediatric solid organ transplantation on cancer risk may differ from those observed in adult recipients. We described cancers in pediatric recipients and compared incidence to the general population.

Methods

The US transplant registry was linked to 16 cancer registries to identify cancer diagnoses among recipients <18 years old at transplant. Standardized incidence ratios (SIRs) were estimated by dividing observed cancer counts among recipients by expected counts based on the general population rates. Cox regression was used to estimate the associations between recipient characteristics and non-Hodgkin's lymphoma (NHL) risk.

Results

Among 17 958 pediatric recipients, 392 cancers were diagnosed, of which 279 (71%) were NHL. Compared with the g

SUBMITTER: Yanik EL 

PROVIDER: S-EPMC5404730 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature