Gene expression study and pathway analysis of histological subtypes of intestinal metaplasia that progress to gastric cancer.

ABSTRACT:

Background

Intestinal metaplasia (IM) is a precursor lesion that precedes gastric cancer (GC). There are two IM histological subtypes, complete (CIM) and incomplete (IIM), the latter having higher progression rates to GC. This study was aimed at analysing gene expression and molecular processes involved in the progression from normal mucosa to IM, and also from IM subtypes to GC.

Methodology

We used expression data to compare the transcriptome of healthy gastric mucosa to that of IM not progressing to GC, and the transcriptome of IM subtypes that had progressed to GC to those that did not progress. Some deregulated genes were validated and pathway analyses were performed.

Results

Comparison of IM subtypes that had progressed to GC with those that did not progress show

SUBMITTER: Companioni O 

PROVIDER: S-EPMC5404762 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature