Brainstem response patterns in deeply-sedated critically-ill patients predict 28-day mortality.

ABSTRACT:

Background and purpose

Deep sedation is associated with acute brain dysfunction and increased mortality. We had previously shown that early-assessed brainstem reflexes may predict outcome in deeply sedated patients. The primary objective was to determine whether patterns of brainstem reflexes might predict mortality in deeply sedated patients. The secondary objective was to generate a score predicting mortality in these patients.

Methods

Observational prospective multicenter cohort study of 148 non-brain injured deeply sedated patients, defined by a Richmond Assessment sedation Scale (RASS) <-3. Brainstem reflexes and Glasgow Coma Scale were assessed within 24 hours of sedation and categorized using latent class analysis. The Full Outline Of Unresponsiveness score (FOUR) was

SUBMITTER: Rohaut B 

PROVIDER: S-EPMC5404790 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature