Ontology highlight
ABSTRACT:
SUBMITTER: Xiao MF
PROVIDER: S-EPMC5404919 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Xiao Mei-Fang MF Xu Desheng D Craig Michael T MT Pelkey Kenneth A KA Chien Chun-Che CC Shi Yang Y Zhang Juhong J Resnick Susan S Pletnikova Olga O Salmon David D Brewer James J Edland Steven S Wegiel Jerzy J Tycko Benjamin B Savonenko Alena A Reeves Roger H RH Troncoso Juan C JC McBain Chris J CJ Galasko Douglas D Worley Paul F PF
eLife 20170323
Memory loss in Alzheimer's disease (AD) is attributed to pervasive weakening and loss of synapses. Here, we present findings supporting a special role for excitatory synapses connecting pyramidal neurons of the hippocampus and cortex with fast-spiking parvalbumin (PV) interneurons that control network excitability and rhythmicity. Excitatory synapses on PV interneurons are dependent on the AMPA receptor subunit GluA4, which is regulated by presynaptic expression of the synaptogenic immediate ear ...[more]