Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated.

ABSTRACT: The mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000. Thus, the nose is sub-stratified into more than a thousand OSN subtypes. Here, we employ and validate an RNA-sequencing-based method to quantify the abundance of all OSN subtypes in parallel, and investigate the genetic and environmental factors that contribute to neuronal diversity. We find that the OSN subtype distribution is stereotyped in genetically identical mice, but varies extensively between different strains. Further, we identify cis-acting genetic variation as the greatest component influencing OSN composition and demonstrate independence from OR function. However, we show that olfactory stimulation with particul

SUBMITTER: Ibarra-Soria X 

PROVIDER: S-EPMC5404925 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature