Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing.

ABSTRACT: A study of genome-wide gene expression in major depressive disorder (MDD) was undertaken in a large population-based sample to determine whether altered expression levels of genes and pathways could provide insights into biological mechanisms that are relevant to this disorder. Gene expression studies have the potential to detect changes that may be because of differences in common or rare genomic sequence variation, environmental factors or their interaction. We recruited a European ancestry sample of 463 individuals with recurrent MDD and 459 controls, obtained self-report and semi-structured interview data about psychiatric and medical history and other environmental variables, sequenced RNA from whole blood and genotyped a genome-wide panel of common single-nucleotide polymorphisms. We

SUBMITTER: Mostafavi S 

PROVIDER: S-EPMC5404932 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature