C1 neurons mediate a stress-induced anti-inflammatory reflex in mice.

ABSTRACT: C1 neurons, located in the medulla oblongata, mediate adaptive autonomic responses to physical stressors (for example, hypotension, hemorrhage and presence of lipopolysaccharides). We describe here a powerful anti-inflammatory effect of restraint stress, mediated by C1 neurons: protection against renal ischemia-reperfusion injury. Restraint stress or optogenetic C1 neuron (C1) stimulation (10 min) protected mice from ischemia-reperfusion injury (IRI). The protection was reproduced by injecting splenic T cells that had been preincubated with noradrenaline or splenocytes harvested from stressed mice. Stress-induced IRI protection was absent in Chrna7 knockout (a7nAChR^-/-) mice and greatly reduced by destroying or transiently inhibiting C1. The protection conferred by C1 stimulatio

SUBMITTER: Abe C 

PROVIDER: S-EPMC5404944 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature