Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.

ABSTRACT:

Background

Alcohol dependence (AD) shows evidence for genetic liability, but genes influencing risk remain largely unidentified.

Methods

We conducted a genomewide association study in 706 related AD cases and 1,748 unscreened population controls from Ireland. We sought replication in 15,496 samples of European descent. We used model organisms (MOs) to assess the role of orthologous genes in ethanol (EtOH)-response behaviors. We tested 1 primate-specific gene for expression differences in case/control postmortem brain tissue.

Results

We detected significant association in COL6A3 and suggestive association in 2 previously implicated loci, KLF12 and RYR3. None of these signals are significant in replication. A suggestive signal in the long noncoding RNA LOC339975 is sign

SUBMITTER: Adkins AE 

PROVIDER: S-EPMC5404949 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature