24-Hour protein, arginine and citrulline metabolism in fed critically ill children - A stable isotope tracer study.

ABSTRACT:

Background & aims

The reference method to study protein and arginine metabolism in critically ill children is measuring plasma amino acid appearances with stable isotopes during a short (4-8 h) time period and extrapolate results to 24-h. However, 24-h measurements may be variable due to critical illness related factors and a circadian rhythm could be present. Since only short duration stable isotope studies in critically ill children have been conducted before, the aim of this study was to investigate 24-h appearance of specific amino acids representing protein and arginine metabolism, with stable isotope techniques in continuously fed critically ill children.

Methods

In eight critically ill children, admitted to the pediatric (n = 4) or cardiovascular (n = 4) intensive car

SUBMITTER: de Betue CTI 

PROVIDER: S-EPMC5404980 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature