Genetic determinants of adiponectin regulation revealed by pregnancy.

ABSTRACT:

Objective

This study investigated genetic determinants of adiponectin during pregnancy to reveal novel biology of adipocyte regulation.

Methods

A genome-wide association study was conducted in 1,322 pregnant women from the Hyperglycemia and Adverse Pregnancy Outcome Study with adiponectin measured at ∼28 weeks of gestation. Variants reaching P < 5×10^-5 for de novo genotyping in two replication cohorts (Genetics of Glycemic regulation in Gestation and Growth N = 522; ECOGENE-21 N = 174) were selected.

Results

In the combined meta-analysis, the maternal T allele of rs900400 located on chr3q25 (near LEKR1/CCNL1) was associated with lower maternal adiponectin (β ± standard error [SE] = -0.18 ± 0.03 standard deviation [SD] of adiponectin per risk allele; P = 1.5

SUBMITTER: Hivert MF 

PROVIDER: S-EPMC5404994 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature