Ontology highlight
ABSTRACT:
SUBMITTER: Diaz MF
PROVIDER: S-EPMC5405000 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Stem cells (Dayton, Ohio) 20170305 5
Mesenchymal stromal cells (MSCs) are believed to mobilize from the bone marrow in response to inflammation and injury, yet the effects of egress into the vasculature on MSC function are largely unknown. Here we show that wall shear stress (WSS) typical of fluid frictional forces present on the vascular lumen stimulates antioxidant and anti-inflammatory mediators, as well as chemokines capable of immune cell recruitment. WSS specifically promotes signaling through NFκB-COX2-prostaglandin E<sub>2< ...[more]