Slow Clearance of Norovirus following Infection with Emerging Variants of Genotype GII.4 Strains.

ABSTRACT: The emergence of new norovirus genotype GII.4 strains is associated with widespread norovirus epidemics. Extended periods of viral shedding can contribute to the epidemic potential of norovirus. To describe the duration of viral shedding in infections with novel emerging GII.4 strains versus infections with previously circulating strains, we performed a prospective cohort study of patients hospitalized with norovirus gastroenteritis during separate winter seasons. Rectal swab samples were obtained at the time of inclusion and weekly during follow-ups. The subgenotype strain was determined from capsid sequences. The outcome was defined by the detection of virus for >14 days (slow clearance) or by the detection of negative samples within 14 days (rapid clearance). Two major epidemic GII.4 st

SUBMITTER: Gustavsson L 

PROVIDER: S-EPMC5405271 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature