A Pan-Genomic Approach to Understand the Basis of Host Adaptation in Achromobacter.

ABSTRACT: Over the past decade, there has been a rising interest in Achromobacter sp., an emerging opportunistic pathogen responsible for nosocomial and cystic fibrosis lung infections. Species of this genus are ubiquitous in the environment, can outcompete resident microbiota, and are resistant to commonly used disinfectants as well as antibiotics. Nevertheless, the Achromobacter genus suffers from difficulties in diagnosis, unresolved taxonomy and limited understanding of how it adapts to the cystic fibrosis lung, not to mention other host environments. The goals of this first genus-wide comparative genomics study were to clarify the taxonomy of this genus and identify genomic features associated with pathogenicity and host adaptation. This was done with a widely applicable approach based on pan-g

SUBMITTER: Jeukens J 

PROVIDER: S-EPMC5405338 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature