Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation.

ABSTRACT:

Background

Omega-3 polyunsaturated fatty acids (n-3 FAs) have several beneficial effects on cardiovascular (CV) disease risk factors. These effects on CV risk profile may be mediated by several factors, including epigenetic modifications. Our objective is to investigate, using genome-wide DNA methylation analyses, methylation changes following an n-3 FA supplementation in overweight and obese subjects and to identify specific biological pathways potentially altered by the supplementation.

Results

Blood leukocytes genome-wide DNA methylation profiles of 36 overweight and obese subjects before and after a 6-week supplementation with 3 g of n-3 FAs were compared using GenomeStudio software. After supplementation, 308 CpG sites, assigned to 231 genes, were differentially methyla

SUBMITTER: Tremblay BL 

PROVIDER: S-EPMC5405524 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature