Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.

ABSTRACT:

Objective

To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI), and pediatric-onset multiple sclerosis (MS) using genetic risk scores (GRS).

Methods

We constructed an instrumental variable for vitamin D (vitD GRS) by computing a GRS for 3 genetic variants associated with levels of 25(OH)D in serum using the estimated effect of each risk variant. A BMI GRS was also created that incorporates the cumulative effect of 97 variants associated with BMI. Participants included non-Hispanic white individuals recruited from over 15 sites across the United States (n = 394 cases, 10,875 controls) and Sweden (n = 175 cases, 5,376 controls; total n = 16,820).

Results

Meta-analysis findings d

SUBMITTER: Gianfrancesco MA 

PROVIDER: S-EPMC5405763 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature