Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD.

ABSTRACT:

Objective

To examine whether a polygenic risk score (PRS) derived from APOE4, CLU, and ABCA7 is associated with CSF biomarkers of Alzheimer disease (AD) pathology and whether higher cardiorespiratory fitness (CRF) modifies the association between the PRS and CSF biomarkers.

Methods

Ninety-five individuals from the Wisconsin Registry for Alzheimer's Prevention were included in these cross-sectional analyses. They were genotyped for APOE4, CLU, and ABCA7, from which a PRS was calculated for each participant. The participants underwent lumbar puncture for CSF collection. β-Amyloid 42 (Aβ₄₂), Aβ₄₀, total tau (t-tau), and phosphorylated tau (p-tau) were quantified by immunoassays, and Aβ₄₂/Aβ₄₀ and tau

SUBMITTER: Schultz SA 

PROVIDER: S-EPMC5405766 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature