Correlation of histopathologic characteristics to protein expression and function in malignant melanoma.

ABSTRACT:

Background

Metastatic melanoma is still one of the most prevalent skin cancers, which upon progression has neither a prognostic marker nor a specific and lasting treatment. Proteomic analysis is a versatile approach with high throughput data and results that can be used for characterizing tissue samples. However, such analysis is hampered by the complexity of the disease, heterogeneity of patients, tumors, and samples themselves. With the long term aim of quest for better diagnostics biomarkers, as well as predictive and prognostic markers, we focused on relating high resolution proteomics data to careful histopathological evaluation of the tumor samples and patient survival information.

Patients and methods

Regional lymph node metastases obtained from ten patients with meta

SUBMITTER: Welinder C 

PROVIDER: S-EPMC5405986 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature