Revealing phenotype-associated functional differences by genome-wide scan of ancient haplotype blocks.

ABSTRACT: Genome-wide scans for positive selection have become important for genomic medicine, and many studies aim to find genomic regions affected by positive selection that are associated with risk allele variations among populations. Most such studies are designed to detect recent positive selection. However, we hypothesize that ancient positive selection is also important for adaptation to pathogens, and has affected current immune-mediated common diseases. Based on this hypothesis, we developed a novel linkage disequilibrium-based pipeline, which aims to detect regions associated with ancient positive selection across populations from single nucleotide polymorphism (SNP) data. By applying this pipeline to the genotypes in the International HapMap project database, we show that genes in the det

SUBMITTER: Onuki R 

PROVIDER: S-EPMC5406033 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature