Fecal microbiota transplantation is a rescue treatment modality for refractory ulcerative colitis.

ABSTRACT:

Background

Fecal microbial transplantation (FMT) provides to replace beneficial bacteria with more favorable microbiomes in recipient with dysbiosis. The aim of the present study was to prospectively investigate the efficacy of FMT by assessing the clinical and endoscopic response in patients with ulcerative colitis (UC) who had failed anti-inflammatory and immunosuppressive therapy.

Methods

In this prospective and uncontrolled study, 30 patients with UC were included. All medications except mesalazine were stopped 4 weeks before FMT. Colonoscopy was performed both before and after FMT. To assess the efficacy of FMT, Mayo scores were calculated at week 0 and week 12. A total of 500 mL extracted fresh fecal suspension was administered into the 30 to 40 cm proximal of terminal

SUBMITTER: Uygun A 

PROVIDER: S-EPMC5406052 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature