Framework for radiation pneumonitis risk stratification based on anatomic and perfused lung dosimetry.

ABSTRACT:

Purpose

To design and apply a framework for predicting symptomatic radiation pneumonitis in patients undergoing thoracic radiation, using both pretreatment anatomic and perfused lung dose-volume parameters.

Materials and methods

Radiation treatment planning CT scans were coregistered with pretreatment [^99mTc]MAA perfusion SPECT/CT scans of 20 patients who underwent definitive thoracic radiation. Clinical radiation pneumonitis was defined as grade ≥ 2 (CTCAE v4 grading system). Anatomic lung dose-volume parameters were collected from the treatment planning scans. Perfusion dose-volume parameters were calculated from pretreatment SPECT/CT scans. Equivalent doses in 2 Gy per fraction were calculated in the lung to account for differences in treatment regimens and spa

SUBMITTER: Dhami G 

PROVIDER: S-EPMC5406240 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature