Optimal Volume of Administration of Intranasal Midazolam in Children: A Randomized Clinical Trial.

ABSTRACT:

Study objective

The optimal intranasal volume of administration for achieving timely and effective sedation in children is unclear. We aimed to compare clinical outcomes relevant to procedural sedation associated with using escalating volumes of administration to administer intranasal midazolam.

Methods

We conducted a randomized, single-blinded, 3-arm, superiority clinical trial. Children aged 1 to 7 years and undergoing laceration repair requiring 0.5 mg/kg intranasal midazolam (5 mg/mL) were block-randomized to receive midazolam using 1 of 3 volumes of administration: 0.2, 0.5, or 1 mL. Procedures were videotaped, with outcome assessors blinded to volume of administration. Primary outcome was time to onset of minimal sedation (ie, score of 1 on the University of Michigan S

SUBMITTER: Tsze DS 

PROVIDER: S-EPMC5406242 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature