Maternal Interleukin Genotypes Are Associated With NICU Outcomes Among Low-Birth-Weight Infants.

ABSTRACT:

Background

Maternal interleukin (IL) single nucleotide polymorphisms (SNPs) are associated with obstetrical outcomes. Conversely, infant SNPs are associated with subsequent neonatal intensive care unit (NICU) outcomes. Little is known about relationships between maternal SNPs and neonatal outcomes.

Purpose

To examine the relationships between maternal IL genotypes and neonatal outcomes.

Methods

An ancillary study was conducted among mothers ( N = 63) who delivered very low-birth-weight infants ( N = 74). Maternal DNA was extracted from breast milk and genotyped. Outcomes included fecal calprotectin, length of stay, scores for neonatal acute physiology with perinatal extension (SNAPPE-II), weight gain, oxygen needs, necrotizing enterocolitis, intraventricular hemorrhag

SUBMITTER: Baumgartel KL 

PROVIDER: S-EPMC5406263 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature