Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model.

ABSTRACT: The high prevalence of zinc deficiency is a global public health concern, and suboptimal maternal zinc consumption has been associated with adverse effects ranging from impaired glucose tolerance to low birthweights. The mechanisms that contribute to altered development and poor health in zinc deficient offspring are not completely understood. To address this gap, we utilized the Danio rerio model and investigated the impact of dietary zinc deficiency on adults and their developing progeny. Zinc deficient adult fish were significantly smaller in size, and had decreases in learning and fitness. We hypothesized that parental zinc deficiency would have an impact on their offspring's mineral homeostasis and embryonic development. Results from mineral analysis showed that parental zinc deficien

SUBMITTER: Beaver LM 

PROVIDER: S-EPMC5406264 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature