Crosstalk and the Dynamical Modularity of Feed-Forward Loops in Transcriptional Regulatory Networks.

ABSTRACT: Network motifs, such as the feed-forward loop (FFL), introduce a range of complex behaviors to transcriptional regulatory networks, yet such properties are typically determined from their isolated study. We characterize the effects of crosstalk on FFL dynamics by modeling the cross regulation between two different FFLs and evaluate the extent to which these patterns occur in vivo. Analytical modeling suggests that crosstalk should overwhelmingly affect individual protein-expression dynamics. Counter to this expectation we find that entire FFLs are more likely than expected to resist the effects of crosstalk (≈20% for one crosstalk interaction) and remain dynamically modular. The likelihood that cross-linked FFLs are dynamically correlated increases monotonically with additional crosstalk,

SUBMITTER: Rowland MA 

PROVIDER: S-EPMC5406374 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature