Effect of a hypoxic microenvironment after radiofrequency ablation on residual hepatocellular cell migration and invasion.

ABSTRACT: Clinical observations have shown that the boundary of tumor ablation is often less than safe border and that the use of radiofrequency ablation (RFA) in the treatment of hepatocellular carcinoma (HCC) may probably accelerate its recurrence and metastasis. RFA can cause the formation of a transition zone between normal liver tissues and necrotic coagulation, where blood stagnation and thrombosis expose residual cancer cells to a hypoxic microenvironment. As the blocked vessels are slowly reperfused, the oxygen supply is gradually restored. Here, HCC cells underwent heat treatment and were cultured under hypoxic conditions to mimic the aforementioned situation, and morphological changes were observed in the surviving cells. Compared with their parental cells, hypoxic HCC cells showed changes

SUBMITTER: Tong Y 

PROVIDER: S-EPMC5406608 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature